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Related Experiment Video

Updated: Jul 4, 2025

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

Comprehensive look at rectal squamous cell carcinoma.

Joana Liz-Pimenta¹, Cátia Ferreira², Alexandra Araújo³

¹Medical Oncology, Centro Hospitalar de Tras-os-montes e Alto Douro EPE, Vila Real, Portugal joanalizpimenta@gmail.com.

BMJ Case Reports

|January 25, 2024

Summary

Chemoradiotherapy offers a successful organ preservation option for advanced rectal squamous cell carcinoma (rSCC). This treatment approach, combined with vigilant surveillance, can lead to long-term remission and prevent recurrence in patients with this rare cancer.

Keywords:

Cancer intervention Chemotherapy Gastrointestinal surgery Radiotherapy

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Area of Science:

Oncology
Gastroenterology

Background:

Rectal squamous cell carcinoma (rSCC) is a rare malignancy, accounting for only 0.5% of all rectal cancers.
rSCC typically presents at advanced stages, often associated with a poor prognosis and limited treatment options.

Observation:

A case study involving an elderly woman with advanced rSCC (stage cT4N1aM0) is presented.
The patient received a combination of chemotherapy (mitomycin and fluoropyrimidine) and radiotherapy, achieving a complete response (CR) with organ preservation.

Findings:

The patient remained disease-free for two years post-treatment, monitored through comprehensive surveillance including imaging and clinical examinations.
This case demonstrates the efficacy of chemoradiotherapy in achieving CR and enabling organ preservation for rSCC.

Implications:

Chemoradiotherapy represents a viable and effective treatment strategy for rectal squamous cell carcinoma, offering the potential for organ preservation.
The findings underscore the importance of rigorous surveillance protocols to detect and manage potential recurrences promptly in rSCC survivors.