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Pragmatic Adaptive Trial for Respiratory Infection in Children (PATRIC) Clinical Registry protocol

Rebecca Pavlos1, Mejbah U Bhuiyan1, Mark Jones2

  • 1Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Nedlands, Western Australia, Australia.

BMJ Open
|January 25, 2024
PubMed

Insights

The Pragmatic Adaptive Trial for Respiratory Infections in Children (PATRIC) Clinical Registry collects data on pediatric acute respiratory infections (ARI) to improve treatment. This registry will inform trials to optimize care for children with ARI.

Area of Science:

  • Pediatric infectious diseases
  • Clinical trial registries
  • Respiratory medicine

Background:

  • Acute respiratory infections (ARI) are a leading cause of hospitalization in children.
  • There are significant knowledge gaps in the effective management of pediatric ARI.
  • Optimizing ARI care requires robust data on current treatments and outcomes.

Purpose of the Study:

  • To establish the Pragmatic Adaptive Trial for Respiratory Infections in Children (PATRIC) Clinical Registry.
  • To evaluate current treatments and outcomes for ARI in diverse pediatric populations.
  • To provide a data platform for future PATRIC clinical trials aimed at optimizing pediatric ARI care.

Main Methods:

  • A single-center, prospective observational registry.
  • Recruitment from a tertiary pediatric Emergency Department in Western Australia.
  • Collection of demographic, clinical, treatment, and outcome data.

Main Results:

  • The registry characterizes antibiotic utilization in children with ARI.
  • It improves understanding of ARI outcomes in pediatric patients.
  • Data collected will inform clinical trials to enhance ARI management.

Conclusions:

  • The PATRIC Clinical Registry is essential for advancing pediatric ARI research.
  • It will facilitate evidence-based improvements in ARI treatment and management.
  • This initiative aims to optimize healthcare outcomes for children suffering from respiratory infections.
Abstract

Keywords:
Clinical trialsPAEDIATRICSREGISTRIESRespiratory infections

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