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Updated: Jul 4, 2025

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
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Act Local, Think Global: IR and Its Role in Immuno-Oncology in Hepatocellular Carcinoma

Pedro Luiz Serrano Uson Junior1, Tanios Bekaii-Saab2

  • 1Department of Oncology, Mayo Clinic Cancer Center, Phoenix, Arizona; Center for Personalized Medicine, Hospital Israelita Albert Einstein, Sao Paulo, SP, Brazil; Department of Oncology, HCOR, Sao Paulo, SP, Brazil.

Journal of Vascular and Interventional Radiology : JVIR
|January 25, 2024
PubMed

Interventional oncology (IO) is evolving rapidly. The treatment landscape of liver cancer is changing rapidly, and immunotherapy combinations have become the standard of care for most patients with advanced hepatocellular carcinoma (HCC). The higher response rates and improved outcomes observed with these agents are leading to initiatives for their earlier incorporation in the course of the disease, including in combination with ablative and transarterial treatment options. The intersectionality of systemic therapies and liver-directed approaches has allowed IO to be at the center stage of a rapidly evolving dynamic field across all stages of HCC. This review article will address the current state of treatment for advanced HCC and the incorporation of these options in both localized and advanced stages along with IO to further enhance the observed benefits.

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