Related Experiment Video

Updated: Aug 7, 2026

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta
10:57

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta

Published on: September 12, 2017

8.5K

miR-130a expression is related to aortic dilation in bicuspid aortic valve children

Borja Antequera-González1, Rosa Collell-Hernández2, Neus Martínez-Micaelo1

  • 1Group of Cardiovascular Research, Pere Virgili Health Research Institute (IISPV), Universitat Rovira i Virgili, 43204, Reus, Spain.

Pediatric Research
|January 25, 2024
PubMed

Insights

Lower miR-130a plasma levels in children with bicuspid aortic valve (BAV) disease indicate aortic dilation. This finding may help identify high-risk pediatric BAV patients for better care planning.

Area of Science:

  • Cardiovascular Research
  • Pediatric Cardiology
  • Molecular Biology

Background:

  • Bicuspid aortic valve (BAV) disease affects 0.5-2% of the population, potentially causing fatal aortic dilation.
  • While adult biomarkers exist, none have been validated in pediatric BAV patients.
  • This study investigates four candidate microRNAs (miRNAs) in children with BAV and aortic dilation.

Purpose of the Study:

  • To evaluate plasma levels of miR-122, miR-130a, miR-486, and miR-718 in a pediatric cohort with BAV.
  • To determine if these miRNAs correlate with aortic dilation in children.
  • To explore the functional pathways associated with identified miRNAs.

Main Methods:

  • Eighty participants aged 4-17 years were enrolled, with 40% of BAV patients exhibiting aortic dilation (z score >2).
  • Plasma samples were analyzed using RT-qPCR to quantify four specific miRNAs.
  • Functional and enrichment analyses were performed for miR-130a.

Main Results:

  • Plasma miR-130a levels were significantly lower in BAV patients with aortic dilation compared to non-dilated BAV patients and healthy controls.
  • miR-130a expression showed an inverse correlation with ascending aorta and aortic root z scores.
  • Enrichment analysis indicated that miR-130a targets are involved in the TGFβ signaling pathway.

Conclusions:

  • Decreased plasma miR-130a expression is associated with aortic dilation in pediatric BAV patients.
  • miR-130a may serve as a valuable biomarker for differentiating risk levels in children with BAV.
  • This research is the first to analyze miRNA patterns in pediatric BAV patients with aortic dilation, aiding in risk stratification and care planning.
Abstract

More Related Videos

A Closed-chest Model to Induce Transverse Aortic Constriction in Mice08:10

A Closed-chest Model to Induce Transverse Aortic Constriction in Mice

Published on: April 5, 2018

19.1K
Surgery and Sample Processing for Correlative Imaging of the Murine Pulmonary Valve07:34

Surgery and Sample Processing for Correlative Imaging of the Murine Pulmonary Valve

Published on: August 5, 2021

2.6K

Related Concept Videos

Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...