Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Microbial Biosensors

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Protein Binding and Molecular Size Govern Molecular Transport into Dermal Interstitial Fluid.

ACS sensors·2026

Same author

Investigation of effects of collection conditions on amino acid concentrations in sweat and correlations with their Circulating levels in plasma.

Scientific reports·2025

Same author

Discretised microfluidics for noninvasive health monitoring using sweat sensing.

Lab on a chip·2024

Same author

The challenges and promise of sweat sensing.

Nature biotechnology·2024

Same author

Continuous molecular monitoring of human dermal interstitial fluid with microneedle-enabled electrochemical aptamer sensors.

Lab on a chip·2023

Same author

Diverse Drug Classes Partition into Human Sweat: Implications for Both Sweat Fundamentals and for Therapeutic Drug Monitoring.

Therapeutic drug monitoring·2023

Search research articles

Related Experiment Video

Updated: Jul 12, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

Wearing the Lab: Advances and Challenges in Skin-Interfaced Systems for Continuous Biochemical Sensing.

Zach Watkins¹, Adam McHenry², Jason Heikenfeld²

¹Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, USA. watkinzl@mail.uc.edu.

Advances in Biochemical Engineering/Biotechnology

|January 25, 2024

Summary

Wearable biosensors offer continuous health data, similar to continuous glucose monitoring. Challenges in sensitivity, calibration, and longevity remain for widespread use in personalized health and performance optimization.

Keywords:

Biosensing Electrochemical Interstitial fluid Optical Sweat Wearables

More Related Videos

Bridging the Bio-Electronic Interface with Biofabrication

Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

Published on: February 10, 2014

Related Experiment Videos

Last Updated: Jul 12, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

Bridging the Bio-Electronic Interface with Biofabrication

Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

Published on: February 10, 2014

Area of Science:

Biomedical Engineering
Wearable Technology
Biosensing

Background:

Continuous monitoring of individual biomarkers is crucial for personalized health and performance.
Continuous glucose monitoring (CGM) has significantly improved diabetes care.
Wearable biosensing technologies are advancing for monitoring various analytes non-invasively.

Purpose of the Study:

To propose a framework for developing wearable skin-interfaced biosensors.
To assess the feasibility of monitoring analytes in sweat and interstitial fluid.
To highlight advancements and remaining challenges in wearable biosensing.

Main Methods:

Focus on engineering biorecognition elements for enhanced specificity.
Development of robust signal transduction mechanisms for accurate detection.
Novel integration schemes for continuous quantitative analysis in wearable devices.

Main Results:

Recent advances enable monitoring of clinically relevant analytes via minimally invasive devices.
Engineering of biorecognition elements and signal transduction shows promise.
Novel integration schemes facilitate continuous quantitative analysis.

Conclusions:

Wearable biosensors hold significant potential for disease management and performance optimization.
Key challenges include sensitivity, specificity, calibration, and device longevity.
Further development is needed to translate these technologies into commercially viable products.