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Updated: Jul 4, 2025

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
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Rationale for CD40 pathway blockade in autoimmune rheumatic disorders

Valentina Pucino1, David H Gardner2, Benjamin A Fisher1

  • 1Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK; National Institute for Health Research, Birmingham Biomedical Research Centre and Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

The Lancet. Rheumatology
|January 26, 2024
PubMed

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