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Updated: Jul 4, 2025
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Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice
Published on: January 9, 2019
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Electrically Evoked Auditory Brainstem Response Using Extracochlear Stimulation at Different Cochlear Sites: A
Woongsang Sunwoo1, Woonhoe Goo2, Seung-Ha Oh2
1Department of Otorhinolaryngology-Head and Neck Surgery, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.
Clinical and Experimental Otorhinolaryngology
|January 26, 2024
Summary
Extracochlear auditory brainstem response (eEABR) tests correlate with spiral ganglion neuron (SGN) function, offering a way to estimate SGN extent before cochlear implantation.
Area of Science:
- Neuroscience
- Auditory Neuroscience
- Otoacoustic Emissions
Background:
- Spiral ganglion neurons (SGNs) are crucial for hearing.
- Assessing SGN distribution and excitability preoperatively is vital for cochlear implant success.
- Electrically evoked auditory brainstem response (EABR) is used to evaluate SGNs.
Purpose of the Study:
- To investigate extracochlear EABR (eEABR) as a preoperative tool.
- To estimate the distribution and extent of excitable SGNs.
- To correlate eEABR with EABR and auditory thresholds.
Main Methods:
- Used Sprague-Dawley rats (normal hearing and partially deafened).
- Performed extracochlear and intracochlear electrode placements for eEABR and EABR recordings.
- Compared slope characteristics, auditory thresholds, and SGN density.
Main Results:
- eEABR slopes correlated with EABR slopes in normal-hearing rats.
- Auditory thresholds correlated with eEABR slopes in partially deaf rats.
- Stimulation region impacted eEABR slopes based on neural condition.
Conclusions:
- eEABR slopes show spatial correlation with auditory nerve functionality.
- eEABR testing at various cochlear positions can estimate excitable SGN extent.
- eEABR is a promising preoperative test for cochlear implant candidates.
