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Updated: Jul 4, 2025

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System

Published on: August 9, 2017

How variable progenitor clones construct a largely invariant neocortex.

Zhongfu Shen¹, Jiajun Yang¹, Qiangqiang Zhang¹

¹New Cornerstone Science Laboratory, IDG/McGovern Institute for Brain Research, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing 100084, China.

National Science Review

|January 26, 2024

Summary

This summary is machine-generated.

Radial glial progenitors (RGPs) build the mouse neocortex through a constrained yet variable process. This Poisson-like neurogenesis ensures reliable layer formation despite individual cell division differences.

Keywords:

clonal variability intermediate progenitor layer formation neocortex neurogenesis radial glial progenitor

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Cortical Neurogenesis: Transitioning from Advances in the Laboratory to Cell-Based Therapies

Cortical Neurogenesis: Transitioning from Advances in the Laboratory to Cell-Based Therapies

Published on: July 19, 2007

Related Experiment Videos

Last Updated: Jul 4, 2025

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System

Published on: August 9, 2017

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM

Published on: May 8, 2020

Cortical Neurogenesis: Transitioning from Advances in the Laboratory to Cell-Based Therapies

Cortical Neurogenesis: Transitioning from Advances in the Laboratory to Cell-Based Therapies

Published on: July 19, 2007

Area of Science:

Neuroscience
Developmental Biology
Cell Biology

Background:

The neocortex features diverse neurons organized into layers.
Radial glial progenitors (RGPs) generate nearly all neocortical neurons.
Mechanisms for reliable and robust neocortical construction remain unclear.

Purpose of the Study:

To investigate the division behavior and neuronal output of RGPs.
To understand how RGPs contribute to the reliable and robust construction of the neocortex.

Main Methods:

Analysis of RGP division patterns.
Modeling of neurogenic processes.
Examination of neuronal output and layer occupation.

Main Results:

RGP division behavior and neuronal output are constrained with patterned variability.
Neocortical neurogenesis approximates a consistent Poisson-like process over time.
Neuronal output variability is systematically constrained, supporting layer formation.

Conclusions:

RGP neurogenesis exhibits a balance of reliability and variability.
This balance is crucial for constructing the complex neocortical structure.
Variability arises from intermediate progenitor generation and RGP cell cycle timing.