Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Combined phenytoin and salicylate effects on thyroid function tests.

N G Baranetsky, B S Chertow, M D Webb

    Archives Internationales De Pharmacodynamie Et De Therapie
    |November 1, 1986
    PubMed
    Summary

    Salicylates (ASA) combined with phenytoin (DPH) significantly alter thyroid function tests (TFTs). This interaction can lead to further decreases in thyroid hormones, requiring careful interpretation of TFT results in patients on both medications.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Leafhopper subfamily Ledrinae of the Indian subcontinent: 2. Genera Digitata Wang, Li & Dai, Latycephala McKamey, Petalocephala Stl and Thlasia Germar (Hemiptera: Cicadellidae) with description of six new species.

    Zootaxa·2025
    Same author

    The Magnetic Search Coil (MSC) on the TRACERS Mission.

    Space science reviews·2025
    Same author

    Review of the Monobazus-group leafhopper genera (Hemiptera: Cicadellidae: Deltocephalinae) from the Indian subcontinent with description of five new genera and twenty-eight new species.

    Zootaxa·2025
    Same author

    Opsiini leafhopper genus Libengaia Linnavuori (Hemiptera: Cicadellidae: Deltocephalinae) in Africa and India with description of one new subgenus and six new species.

    Zootaxa·2024
    Same author

    Review of the leafhopper genus Drabescus Stl (Hemiptera: Cicadellidae: Deltocephalinae) in the Indian subcontinent with description of one new species.

    Zootaxa·2022
    Same author

    Four new species of Mileewini leafhoppers (Hemiptera: Cicadellidae: Mileewinae) from China, with a checklist to Chinese species.

    Zootaxa·2021

    Area of Science:

    • Endocrinology
    • Pharmacology

    Background:

    • Phenytoin (DPH) is known to affect thyroid function tests (TFTs).
    • Salicylates, such as aspirin (ASA), can also influence thyroid hormone levels.

    Purpose of the Study:

    • To investigate the combined effects of ASA and DPH on TFTs in adult patients.
    • To understand how ASA modifies DPH's impact on thyroid hormone levels.

    Main Methods:

    • Adult patients receiving DPH to achieve steady-state serum levels.
    • Stepwise administration of ASA (325, 650, 975 mg q 4hr) at 2-day intervals.
    • Measurement of TFTs, total serum, and free salivary DPH levels.

    Main Results:

    • Therapeutic DPH levels decreased free thyroxine (FT4), total T4, and total T3 (TT3), while slightly increasing T3 resin uptake (T3RU).

    Related Experiment Videos

  • Co-administration of ASA with DPH further decreased total T4, TT3, and FT4, and reduced T3RU.
  • Despite hormonal changes, TSH levels remained within the normal range throughout the study.

    • Conclusions:

    • Combined ASA and DPH therapy causes significant alterations in TFTs, necessitating cautious interpretation.
    • Observed changes suggest ASA displaces T4 from binding proteins and DPH increases FT4 clearance.