Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

51
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
51
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
Bone Disorders01:29

Bone Disorders

3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Mitochondria01:37

Mitochondria

12.6K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
12.6K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

487
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
487
Telomeres and Telomerase02:41

Telomeres and Telomerase

5.2K
5.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lysosome-derived methylated arginine is a signalling metabolite controlling the lipidome.

Nature cell biology·2026
Same author

Regional and Systemic Metabolic Remodeling Promotes Longevity by Bioengineered Yeast-Derived Lipids.

bioRxiv : the preprint server for biology·2026
Same author

Age-Driven Lipid Remodeling Activates Lysosome-Mediated Plasma Membrane Repair.

Research square·2026
Same author

The visual system of the longest-living vertebrate, the Greenland shark.

Nature communications·2026
Same author

Dysregulated DNA Methylation in <i>Abca4<sup>-/-</sup></i> Retinal Pigment Epithelium: Insights into Early Stage of Stargardt Disease.

International journal of molecular sciences·2025
Same author

Retinal polyunsaturated fatty acid supplementation reverses aging-related vision decline in mice.

Science translational medicine·2025

Related Experiment Video

Updated: Jul 4, 2025

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

3.4K

Hallmarks of Aging: Causes and Consequences.

Dorota Skowronska-Krawczyk1

  • 1Department of Physiology and Biophysics, Department of Ophthalmology, Center for Translational Vision Research, School of Medicine, University of California, Irvine, CA, USA.

Aging Biology
|January 26, 2024
PubMed
Summary

This study proposes a new model for aging, shifting focus from the 12 hallmarks of aging to the sequential, molecular origins and cellular responses that drive the aging process. This framework aims to advance aging research and investigation.

More Related Videos

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
08:52

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Published on: April 6, 2022

3.5K
A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

8.3K

Related Experiment Videos

Last Updated: Jul 4, 2025

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

3.4K
Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
08:52

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Published on: April 6, 2022

3.5K
A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

8.3K

Area of Science:

  • Gerontology
  • Molecular Biology
  • Cellular Biology

Background:

  • The 12 hallmarks of aging provide a framework for understanding aging phenotypes.
  • Aging involves complex, interrelated processes throughout an organism's lifespan.
  • Existing models may not fully capture the sequential and causative nature of aging.

Purpose of the Study:

  • To propose a novel model for aging that emphasizes mechanistic complexity.
  • To shift focus from categorization to the sequential and causative aspects of aging.
  • To stimulate discussion and guide future research in the aging field.

Main Methods:

  • Literature review and synthesis of existing aging research.
  • Conceptual model development based on mechanistic understanding.
  • Analysis of molecular origins and cellular/tissue responses in aging.

Main Results:

  • Identified limitations in current hallmark-based aging models.
  • Proposed a new model distinguishing early molecular origins from later responses.
  • Highlighted the sequential and causative nature of age-related changes.

Conclusions:

  • The proposed model offers a new perspective on aging mechanisms.
  • This approach may better guide future aging research and therapeutic strategies.
  • Further discussion and investigation are needed to validate the proposed model.