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Thermal Ablation for the Treatment of Abdominal Tumors
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Chemoembolization Plus Ablation: Current Status.

Farnaz Dadrass1, Pascal Acree2, Edward Kim1

  • 1Department of Diagnostic, Molecular and Interventional Radiology, Mount Sinai Hospital, New York, New York.

Seminars in Interventional Radiology
|January 26, 2024
PubMed
Summary
This summary is machine-generated.

Transarterial chemoembolization (TACE)-ablation offers a viable treatment for early-stage hepatocellular carcinoma (HCC) lesions between 3 and 5 cm. While surgical resection is the gold standard, TACE-ablation shows promise, though further research is needed against newer therapies.

Keywords:
TACE–ablationablationchemoembolizationhepatocellular carcinomainterventional oncologyinterventional radiology

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Area of Science:

  • Hepatology
  • Oncology
  • Interventional Radiology

Background:

  • Hepatocellular carcinoma (HCC) is a major global cause of cancer mortality.
  • Treatment for HCC has advanced, yet optimal strategies for specific lesion sizes remain debated.
  • The Barcelona Clinic Liver Cancer (BCLC) system guides treatment but requires nuanced application for intermediate lesions.

Purpose of the Study:

  • To review and analyze treatments for early-stage HCC lesions measuring 3-5 cm.
  • To evaluate the efficacy and therapeutic potential of transarterial chemoembolization (TACE)-ablation for these lesions.
  • To compare TACE-ablation with other therapies like surgical resection, transarterial radioembolization, and standard TACE.

Main Methods:

  • Literature review of existing studies on HCC treatments.
  • Comparative analysis of TACE-ablation against other therapeutic modalities.
  • Focus on evidence for lesions within the 3-5 cm size range.

Main Results:

  • Transarterial chemoembolization (TACE)-ablation is identified as a feasible treatment option for 3-5 cm HCC.
  • Surgical resection is confirmed as the current gold standard for early-stage HCC.
  • Radiation segmentectomy emerges as a potential curative option, requiring further comparative studies.

Conclusions:

  • TACE-ablation presents a valuable therapeutic choice for early-stage HCC (3-5 cm).
  • While surgical resection remains superior, TACE-ablation offers an alternative.
  • Further research is essential to establish the comparative effectiveness of TACE-ablation and radiation segmentectomy.