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Updated: Jul 31, 2026

Thermal Ablation for the Treatment of Abdominal Tumors
Published on: March 7, 2011
Thermal Ablation in the Liver: Heat versus Cold-What Is the Role of Cryoablation?
Donna L D'Souza1, Ranjan Ragulojan1, Chunxiao Guo1
1Division of Interventional Radiology, Department of Radiology, University of Minnesota, Minneapolis, Minnesota.
Abstract:
Cryoablation is commonly used in the kidney, lung, breast, and soft tissue, but is an uncommon choice in the liver where radiofrequency ablation (RFA) and microwave ablation (MWA) predominate. This is in part for historical reasons due to serious complications that occurred with open hepatic cryoablation using early technology. More current technology combined with image-guided percutaneous approaches has ameliorated these issues and allowed cryoablation to become a safe and effective thermal ablation modality for treating liver tumors. Cryoablation has several advantages over RFA and MWA including the ability to visualize the ice ball, minimal procedural pain, and strong immunomodulatory effects. This article will review the current literature on cryoablation of primary and secondary liver tumors, with a focus on efficacy, safety, and immunogenic potential. Clinical scenarios when it may be more beneficial to use cryoablation over heat-based ablation in the liver, as well as directions for future research, will also be discussed.
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