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Related Concept Videos

Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

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The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
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Anatomy of the Intestines01:23

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Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
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Essential Minerals for Bone Health01:31

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Anatomy of the Gastrointestinal System01:26

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The human digestive system is an intricate and essential network for nutrient absorption and waste elimination. It encompasses the gastrointestinal (GI) tract and several accessory organs.
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Role of Vitamins in Maintaining Bone Health01:25

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
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The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
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Related Experiment Video

Updated: Jul 4, 2025

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
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Bones and guts - Why the microbiome matters.

Kelly F Contino1, Katherine L Cook1, Yusuke Shiozawa1

  • 1Department of Cancer Biology, Wake Forest University School of Medicine, and Atrium Health Wake Forest Baptist Comprehensive Cancer, Winston-Salem, NC, USA.

Journal of Bone Oncology
|January 26, 2024
PubMed
Summary
This summary is machine-generated.

The gut microbiome influences bone health, an emerging field called osteomicrobiology. This area explores the gut bacteria

Keywords:
Bacteria supplementationBone metastasisBone remodelingGut microbiotaOsteomicrobiology

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Area of Science:

  • Microbiology
  • Bone Biology
  • Oncology

Background:

  • Gut microbiota plays a crucial role in human health.
  • Gut dysbiosis is linked to various diseases.
  • The gut microbiome's influence on bone biology is a recent discovery.

Purpose of the Study:

  • Introduce osteomicrobiology as an emerging field.
  • Review the current understanding of the gut microbiome's role in bone health and disease.
  • Explore the connection between gut bacteria and bone metastasis in cancer.

Main Methods:

  • Literature review of osteomicrobiology research.
  • Analysis of studies linking gut microbiota to bone biology.
  • Examination of research on gut bacteria and bone metastasis.

Main Results:

  • Osteomicrobiology is an emerging field investigating the gut-bone axis.
  • Gut dysbiosis negatively impacts bone health.
  • The gut microbiome is increasingly implicated in bone metastasis.

Conclusions:

  • Osteomicrobiology offers insights into bone health and disease.
  • Understanding the gut-bone axis is critical for bone metastasis research.
  • Further exploration of gut bacteria's role in bone cancer is warranted.