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Published on: June 23, 2020
Evaluation of Novel Dendrimer-Gold Complex Nanoparticles for Theranostic Application in Oncology
Nevena Milivojević1,2,3, Mariana R Carvalho4,5, David Caballero4,5
1University of Kragujevac, Liceja Kneževine Srbije 1A, 34000, Kragujevac, Serbia.
Aim:
Despite some successful examples of therapeutic nanoparticles reaching clinical stages, there is still a significant need for novel formulations in order to improve the selectivity and efficacy of cancer treatment.
Methods:
The authors developed two novel dendrimer-gold (Au) complex-based nanoparticles using two different synthesis routes: complexation method (formulation A) and precipitation method (formulation B). Using a biomimetic cancer-on-a-chip model, the authors evaluated the possible cytotoxicity and internalization by colorectal cancer cells of dendrimer-Au complex-based nanoparticles.
Results:
The results showed promising capabilities of these nanoparticles for selectively targeting cancer cells and delivering drugs, particularly for the formulation A nanoparticles.
Conclusion:
This work highlights the potential of dendrimer-Au complex-based nanoparticles as a new strategy to improve the targeting of anticancer drugs.
