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Tuberculosis and kidney transplantation.

H Riska, B Kuhlbäck

    Acta Medica Scandinavica
    |January 1, 1979
    PubMed
    Summary

    Kidney transplant patients on immunosuppressive drugs face increased infection risks, including tuberculosis. While antituberculous treatment was effective, tuberculosis negatively impacted survival rates in these patients.

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    Area of Science:

    • Nephrology
    • Infectious Diseases
    • Transplantation Immunology

    Background:

    • Immunosuppressive therapy is crucial for transplant recipients but increases susceptibility to infections.
    • Tuberculosis (TB) is a known opportunistic infection in immunocompromised individuals, particularly organ transplant recipients.

    Purpose of the Study:

    • To investigate the incidence and outcomes of pulmonary tuberculosis in kidney transplant patients.
    • To evaluate the effectiveness of antituberculous treatment and its impact on graft and patient survival.

    Main Methods:

    • Retrospective analysis of 584 kidney transplant patients.
    • Identification of patients who developed pulmonary tuberculosis post-transplantation.
    • Review of treatment protocols and patient outcomes, including graft and survival rates.

    Main Results:

    • Ten out of 584 kidney transplant patients developed pulmonary tuberculosis during immunosuppressive treatment.
    • One patient with a history of TB experienced a relapse without prophylactic treatment.
    • Routine antituberculous treatment showed excellent results for TB infection itself.
    • Graft and patient survival rates were disappointing among patients who developed tuberculosis.

    Conclusions:

    • Pulmonary tuberculosis is a significant complication in kidney transplant recipients under immunosuppression.
    • While TB is treatable, its occurrence is associated with poor long-term outcomes, including reduced graft and patient survival.

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