Related Experiment Video

Updated: Jul 4, 2025

Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

21.2K

The Therapeutic Potential of Pericytes in Bone Tissue Regeneration

Assel Issabekova1, Gulshakhar Kudaibergen1, Aliya Sekenova1

  • 1Stem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan.

Biomedicines
|January 26, 2024
PubMed

Insights

Pericytes, perivascular cells crucial for tissue repair, show promise in bone regeneration. Combining them with osteogenic factors and scaffolds effectively restores bone defects, offering new therapeutic potential.

Area of Science:

  • Cell Biology
  • Regenerative Medicine
  • Biomaterials Science

Background:

  • Pericytes are perivascular cells integral to vascularized tissues, regulating blood pressure and participating in regeneration and scarring.
  • Pericytes are confirmed to be vital in bone tissue regeneration via osteodifferentiation, paracrine signaling, and promoting vascularization.

Purpose of the Study:

  • To review the characteristics of pericytes and their roles in angiogenesis and osteogenesis.
  • To explore recent advancements in preclinical and clinical applications of pericytes for bone defect repair.

Main Methods:

  • Literature review focusing on pericyte biology and their therapeutic applications.
  • Analysis of preclinical and clinical studies investigating pericyte-based bone regeneration strategies.

Main Results:

  • Pericytes exhibit multifaceted roles in angiogenesis and osteogenesis, essential for bone healing.
  • Therapeutic strategies combining pericytes with osteogenic factors and scaffolds demonstrate efficacy in preclinical and clinical settings for bone defect restoration.

Conclusions:

  • Pericytes possess significant therapeutic potential for treating bone-related medical conditions.
  • The integration of pericytes into tissue-engineered constructs represents a promising avenue for clinical applications in bone regeneration.

Keywords:
bone defectosteogenesispericyteregeneration

More Related Videos

Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles10:07

Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles

Published on: May 26, 2017

9.2K
Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue08:15

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Published on: October 8, 2016

7.4K

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.7K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K