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Post-COVID-19 Vaccination Myocarditis: A Histopathologic Study on a Monocentric Series of Six Cases

Hyo-Suk Ahn1,2, Yuran Ahn1,2, Jaehyuk Jang1,2

  • 1Division of Cardiology, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Republic of Korea.

Diagnostics (Basel, Switzerland)
|January 26, 2024
PubMed

Insights

Post-COVID-19 vaccination myocarditis (PCVM) often shows mild inflammation on endomyocardial biopsy. Some cases may not meet Dallas criteria, indicating borderline myocarditis.

Area of Science:

  • Cardiology
  • Pathology
  • Immunology

Background:

  • Reports of myocarditis following COVID-19 vaccination (PCVM) are increasing.
  • Few studies have examined endomyocardial biopsy (EMB) findings in PCVM.

Purpose of the Study:

  • To describe the clinicopathologic features of PCVM.
  • To analyze EMB results in patients with suspected PCVM.

Main Methods:

  • Retrospective analysis of hospitalized patients at a single university hospital.
  • Identification and detailed review of six PCVM cases.
  • All six patients underwent endomyocardial biopsy (EMB).

Main Results:

  • Six PCVM cases identified (five male, age 15-85).
  • All patients exhibited cardiac dysfunction; two mild, four with dilated cardiomyopathy.
  • Histopathology revealed lymphohistiocytic myocarditis in all cases.
  • Two cases met CD3+ T lymphocyte criteria; four did not meet Dallas criteria.

Conclusions:

  • Most PCVM cases exhibit mild histopathological inflammation.
  • Some PCVM cases may be classified as borderline myocarditis, not meeting traditional diagnostic criteria.

Keywords:
COVID-19 vaccinationendomyocardial biopsymyocarditis

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