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Author Spotlight: The Significance of Isolation, Culture, and Adipogenic Induction of SVF-Derived Preadipocytes from Mouse Perivascular Adipose Tissue
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Pericytes as the Orchestrators of Vasculature and Adipogenesis

Caroline de Carvalho Picoli1, Alexander Birbrair2, Ziru Li1

  • 1Center for Molecular Medicine, MaineHealth Institute for Research, Scarborough, ME 04074, USA.

Genes
|January 26, 2024
PubMed

Insights

Pericytes (PCs), crucial for blood vessel health, are also stem cells in fat tissue. Understanding PC markers aids in targeting metabolic and bone diseases.

Area of Science:

  • Cell Biology
  • Vascular Biology
  • Adipose Tissue Biology

Background:

  • Pericytes (PCs) are perivascular cells integral to microvessel stability and function.
  • PCs possess multi-potent stem/progenitor cell properties within various adipose tissues.
  • The heterogeneity and precise identification of PCs present significant research challenges.

Purpose of the Study:

  • To review common pericyte markers used in lineage-tracing studies.
  • To highlight the role of pericytes in adipogenesis across different adipose depots.
  • To discuss pericyte functions under various metabolic conditions.

Main Methods:

  • Literature review of pericyte markers.
  • Analysis of lineage-tracing studies involving pericytes.
  • Synthesis of data on pericyte contribution to adipogenesis and function.

Main Results:

  • Multiple markers are utilized for pericyte identification and lineage tracing.
  • Pericytes contribute to the development and function of white, brown, and beige adipose tissues.
  • Pericyte behavior and function are modulated by metabolic state.

Conclusions:

  • A deeper understanding of pericyte heterogeneity is essential for therapeutic applications.
  • Targeting pericytes may offer novel strategies for treating metabolic and bone-related disorders.
  • Further research into pericyte markers and functions can unlock their therapeutic potential.

Keywords:
adipogenesisadipose tissuehallmarkspericytes

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