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Updated: Jul 4, 2025

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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Leptin and Leptin Receptor Polymorphisms in Infants and Their Parents: Correlation with Preterm Birth

Francesco Savino1, Allegra Sardo1, Stefano Gambarino2

  • 1Early Infancy Special Care Unit, Regina Margherita Children Hospital, A.O.U. Città della Salute e della Scienza di Torino, 10126 Torino, Italy.

Genes
|January 26, 2024
PubMed

Insights

Genetic variations in LEP and LEPR genes are linked to adverse pregnancy outcomes. This study found a father

Area of Science:

  • Genetics
  • Obstetrics
  • Perinatology

Background:

  • Single-nucleotide polymorphisms (SNPs) in LEP and LEPR genes are associated with adverse pregnancy outcomes (PAOs).
  • Preterm birth (PTB) is a leading cause of infant mortality, necessitating research into its genetic underpinnings.

Purpose of the Study:

  • To investigate the correlation between specific LEP and LEPR gene single-nucleotide polymorphisms (SNPs) and the occurrence of preterm birth (PTB).

Main Methods:

  • Genotyping of three SNPs (LEPRA668G, LEPG2548A, A19G) in oral mucosa cells from families with spontaneous PTB and control families with at-term births.
  • Analysis using ARMS-MAMA real-time PCR.

Main Results:

  • No significant association was found between LEPG2548A or LEPA19G SNPs and PTB in infants, mothers, or fathers.
  • A statistically significant correlation was observed between the LEPRA668G genotype GG in fathers and PTB.

Conclusions:

  • The LEPRA668G genotype in fathers may represent a genetic risk factor contributing to preterm birth.
  • Further research is required to elucidate the precise role of genetics in preterm delivery.

Keywords:
buccal swabgeneticsinfantsleptinleptin receptorparentspolymorphismspreterm birth

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