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Updated: Jul 4, 2025

Nuclear Migration in the Drosophila Oocyte
Published on: May 13, 2021
The Importance of the Position of the Nucleus in Drosophila Oocyte Development
Jean-Antoine Lepesant1, Fanny Roland-Gosselin1, Clémentine Guillemet1
1Université Paris Cité, CNRS, Institut Jacques Monod, 75013 Paris, France.
Abstract:
Oogenesis is a developmental process leading to the formation of an oocyte, a haploid gamete, which upon fertilisation and sperm entry allows the male and the female pronuclei to fuse and give rise to a zygote. In addition to forming a haploid gamete, oogenesis builds up a store of proteins, mRNAs, and organelles in the oocyte needed for the development of the future embryo. In several species, such as Drosophila, the polarity axes determinants of the future embryo must be asymmetrically distributed prior to fertilisation. In the Drosophila oocyte, the correct positioning of the nucleus is essential for establishing the dorsoventral polarity axis of the future embryo and allowing the meiotic spindles to be positioned in close vicinity to the unique sperm entry point into the oocyte.
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