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Natural Products for Cancer Prevention and Interception: Preclinical and Clinical Studies and Funding Opportunities

Edward R Sauter1, Altaf Mohammed2

  • 1Breast and Gynecologic Cancer Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, MD 20850, USA.

Pharmaceuticals (Basel, Switzerland)
|January 26, 2024
PubMed

Insights

Natural products show promise for cancer prevention and interception. Research focuses on human clinical trials for individual agents and preclinical studies for combinations, with funding available for further investigation.

Area of Science:

  • Oncology
  • Pharmacology
  • Natural Products Research

Background:

  • Natural products (NPs) are investigated for cancer prevention and interception.
  • The National Cancer Institute (NCI) seeks novel agents for cancer prevention.
  • Existing research includes individual agents and combination interventions.

Purpose of the Study:

  • To review natural product studies in cancer prevention and interception.
  • To focus on human studies for individual agents and preclinical studies for combinations.
  • To highlight funding opportunities for natural product research in cancer prevention.

Main Methods:

  • Review of human studies, particularly clinical trials, for individual natural product agents.
  • Inclusion of preclinical studies for combination natural product interventions.
  • Analysis of research funded by the NCI's Division of Cancer Prevention (DCP).

Main Results:

  • Preclinical findings for individual agents often lack confirmation in human studies.
  • A limited number of combination intervention studies have been conducted.
  • The NCI's DCP actively funds natural product research in cancer prevention.

Conclusions:

  • Further research is needed to validate natural products for cancer prevention.
  • A balanced approach including human and preclinical studies is essential.
  • NCI funding aims to stimulate innovative natural product research for cancer prevention and interception.
Keywords:
cancer interceptioncancer preventioncombination chemopreventionnatural products

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