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Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Published on: June 7, 2016

Microorganisms and Breast Cancer: An In-Depth Analysis of Clinical Studies.

Naghmeh Naderi^1,2, Afshin Mosahebi^1,2, Norman R Williams²

¹Department of Plastic and Reconstructive Surgery, Royal Free Hospital, London NW3 2QG, UK.

Pathogens (Basel, Switzerland)

|January 26, 2024

Summary

This study reviews 137 clinical trials exploring the links between microorganisms and breast cancer, identifying knowledge gaps and emerging trends for potential prevention and treatment strategies.

Keywords:

bacteria breast neoplasms female fungi viruses

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Area of Science:

Microbiology
Oncology
Clinical Research

Background:

Breast cancer is a significant global health concern.
Emerging research suggests a link between microorganisms (bacteria, viruses, fungi) and breast cancer development.
Understanding this relationship may offer new avenues for prevention and treatment.

Purpose of the Study:

To systematically analyze existing clinical studies on microorganisms and breast cancer.
To identify trends and knowledge gaps in this research area.
To inform future research directions and potential therapeutic strategies.

Main Methods:

Conducted a comprehensive search of ClinicalTrials.gov (117 studies) and PubMed (20 studies).
Utilized a specific set of 38 search terms related to bacteria, viruses, and fungi in breast cancer.
Descriptively analyzed 137 selected studies based on characteristics like geography, interventions, and study status.

Main Results:

The analysis covered a diverse range of studies on the interplay between microbes and breast cancer.
Key characteristics of the studies, including geographical distribution and interventions, were cataloged.
Thematic collation facilitated the identification of current research trends and areas needing further investigation.

Conclusions:

A significant body of clinical research is investigating the role of microorganisms in breast cancer.
The review highlights the need for further research to elucidate specific microbial contributions.
Findings provide a foundation for developing novel microbiome-targeted breast cancer therapies and preventive measures.