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Identifying and Exploring the Impact Factors for Intraocular Pressure Prediction in Myopic Children with Atropine

Tzu-En Wu1,2, Jun-Wei Chen3, Tzu-Chi Liu4

  • 1Department of Ophthalmology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 11101, Taiwan.

Journal of Personalized Medicine
|January 26, 2024
PubMed

Insights

Topical atropine for myopia control in children is safe when baseline intraocular pressure (IOP) is below 14 mmHg. Higher baseline IOP may increase IOP with atropine treatment, necessitating careful monitoring.

Area of Science:

  • Ophthalmology
  • Pediatric Medicine
  • Artificial Intelligence in Healthcare

Background:

  • Topical atropine is a common treatment for childhood myopia, effective in slowing its progression.
  • Monitoring intraocular pressure (IOP) is essential for the safe use of atropine.
  • Establishing a precise baseline IOP is crucial for clinical safety assessments.

Purpose of the Study:

  • To identify the optimal machine learning module for monitoring IOP in children treated with atropine.
  • To establish a precise baseline IOP as a clinical safety reference for atropine therapy.

Main Methods:

  • Retrospective analysis of data from 1545 eyes of 1171 children undergoing atropine treatment for myopia.
  • Utilized a multivariate adaptive regression spline (MARS) model to analyze 19 variables affecting End IOP.
  • Key variables included patient demographics, medical history, refractive error, and IOP measurements.

Main Results:

  • The MARS model identified age, baseline IOP, End Spherical, and atropine treatment durations as significant factors influencing End IOP.
  • Baseline IOP was the most influential factor, with a critical threshold identified at 14 mmHg.
  • A positive correlation between atropine use and End IOP was observed when baseline IOP equaled or exceeded 14 mmHg.

Conclusions:

  • The MARS model effectively captures nonlinearity in predicting End IOP compared to traditional linear regression.
  • Atropine administration may increase IOP in children with a baseline IOP exceeding 14 mmHg.
  • Findings provide critical insights for clinicians to optimize atropine therapy and ensure patient safety.
Abstract

Keywords:
atropineintraocular pressuremultivariate adaptive regression splinesmyopia

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