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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

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A Small Highly Sensitive Glucose Sensor Based on a Glucose Oxidase-Modified U-Shaped Microfiber.

Tingkuo Chen¹, Haiming Jiang¹, Kang Xie¹

¹State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment, School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou 510006, China.

Sensors (Basel, Switzerland)

|January 26, 2024

Summary

This study introduces a novel microfiber sensor for continuous blood glucose monitoring in diabetes patients. The sensor demonstrates high sensitivity and stability, offering a promising tool for improved diabetes management.

Keywords:

U-shaped microfiber evanescent wave glucose oxidase glucose sensor surface modification

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Area of Science:

Biomedical Engineering
Sensor Technology
Analytical Chemistry

Background:

Diabetes mellitus necessitates regular blood glucose monitoring.
Existing monitoring methods may have limitations in sensitivity, stability, or invasiveness.

Purpose of the Study:

To develop and characterize a novel microfiber-based sensor for accurate and sensitive blood glucose detection.
To evaluate the performance of the proposed sensor for potential application in diabetes management.

Main Methods:

Fabrication of a U-shaped microfiber sensor using hydrogen-oxygen flame-heating technology.
Surface functionalization with 3-aminopropyltriethoxysilane (APTES) and glucose oxidase (GOD).
Characterization of sensor morphology using scanning electron microscopy (SEM) and confocal laser microscopy (CLM).

Main Results:

The sensor exhibited a high sensitivity of 5.73 nm/(mg/mL) for glucose detection.
A significant 329% increase in sensitivity was observed compared to similar sensors.
The sensor demonstrated miniaturization, high sensitivity, and good stability.

Conclusions:

The novel U-shaped microfiber sensor offers a highly sensitive and stable platform for blood glucose detection.
This technology holds significant potential for improving blood glucose monitoring in diabetic patients.
The sensor's advantages make it a promising candidate for practical clinical applications.