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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Oral cancer (OC) is a prevalent malignancy with severe chemotherapy side effects.
  • Nanotechnology, particularly nanoparticles (NPs), presents a novel approach for OC management.
  • Nano-drug delivery systems (nano-DDSs) are developed to improve OC therapy efficacy.

Purpose of the Study:

  • To review the potential and limitations of nano-DDSs in oral cancer therapy.
  • To analyze components, mechanisms, and laboratory effects of various nano-DDSs for OC.
  • To provide insights for developing safer and more effective nano-DDSs for OC treatment.

Main Methods:

  • Literature search and analysis of research on nano-DDSs for oral cancer.
  • Evaluation of NP characteristics (size, surface, encapsulation) for controlled drug release and targeting.
  • Assessment of nano-DDSs' impact on drug accumulation in tumor tissues.

Main Results:

  • Certain nano-DDSs enhance drug accumulation in OC tissues, improving therapeutic effects.
  • Nano-DDSs enable targeted drug delivery and controlled release through design modifications.
  • These systems offer personalized OC treatment by improving drug delivery and reducing toxicity.

Conclusions:

  • Nano-DDSs represent a promising strategy for oral cancer therapy, enhancing efficacy and reducing side effects.
  • Challenges including toxicity, precise targeting, biodegradability, and drug-release kinetics need further investigation.
  • Future research should focus on overcoming these limitations to advance nano-DDS application in OC treatment.