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Related Experiment Videos

Radiotherapy for choroidal melanoma. An 18-year experience with radon.

F H Davidorf, J T Pajka, T A Makley

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |March 1, 1987
    PubMed
    Summary

    Radon therapy for choroidal melanoma showed a high survival rate but led to significant vision loss due to radiation-induced retinopathy. Long-term follow-up revealed complications in most patients who retained their eyes.

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    An unusual presentation of a juxtapapillary choroidal melanoma.

    Retina (Philadelphia, Pa.)·1996

    Area of Science:

    • Ophthalmology
    • Oncology
    • Radiation Therapy

    Background:

    • Choroidal melanoma is a rare intraocular malignancy.
    • Radon therapy has been used historically for treating choroidal melanoma.

    Purpose of the Study:

    • To evaluate the long-term outcomes of radon therapy for choroidal melanoma.
    • To assess survival rates and complications associated with this treatment.

    Main Methods:

    • Retrospective review of 23 patients treated with radon therapy between 1968-1976.
    • Minimum follow-up of 8 years for all patients.

    Main Results:

    • 18-year experience with 16 patients (69.6%) alive with no metastatic disease.
    • 3 patients (13%) died of metastatic disease; 4 (17.4%) died of other causes.

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  • 8 patients required enucleation; 13 of 15 eye-retaining patients developed irradiation-induced retinopathy.

    • Conclusions:

    • Radon therapy offers a high survival rate for choroidal melanoma.
    • Significant rates of vision-impairing retinopathy and complications occur even with successful tumor control.