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Investigation of hemorheological parameters in patients with major depressive disorder
Yasemin Yildiz1, Emre Mutlu2, Okan Arihan3
1Department of Physiology, Gülhane Faculty of Medicine, Health Sciences University, Ankara, Turkey.
Insights
Major depressive disorder is linked to unfavorable hemorheological changes, including higher plasma viscosity and reduced erythrocyte elongation. These alterations may increase cardiovascular disease risk in depressed individuals.
Area of Science:
- Cardiovascular Physiology
- Hematology
- Psychiatry
Background:
- Cardiovascular disease (CVD) is linked to altered hemorheological parameters.
- Major depressive disorder (MDD) is a known risk factor for CVD.
Purpose of the Study:
- To investigate hemorheological parameter disturbances in MDD patients.
- To explore the relationship between hemorheology and depressive symptomatology.
Main Methods:
- Compared hemorheological parameters in 50 MDD patients and 50 controls.
- Assessed plasma viscosity, erythrocyte aggregation, and deformability.
Main Results:
- MDD patients exhibited significantly higher plasma viscosity.
- Erythrocyte elongation index was significantly lower in MDD patients.
- Specific hematological indices (MCV, MCH, MCHC) were also lower in the MDD group.
Conclusions:
- Elevated plasma viscosity and reduced erythrocyte elongation in MDD suggest unfavorable hemorheology.
- These hemorheological changes may contribute to the increased CVD risk associated with depression.
- Findings support a potential causal link between MDD, hemorheological alterations, and cardiovascular events.
Background:
Hemorheological parameters have been reported to be altered in cardiovascular disease. Major depression has been associated with increased risk of cardiovascular disease.
Objective:
Our hypothesis is that hemorheological parameters are disturbed in major depressive disorder.
Methods:
Major depressive disorder and control groups consisted of 50 subjects. Plasma viscosity, erythrocyte aggregation, erythrocyte deformability, hematological parameters and hematological parameters were examined.
Results:
Plasma viscosity was statistically significantly higher, erythrocyte elongation index at 0.53 Pa and 0.95 Pa was lower, and MCV, MCH, and MCHC values were also lower in the major depression group (P < 0.05). Elongation index and plasma viscosity were correlated with depressive symptomatology.
Conclusions:
The increased plasma viscosity and decreased elongation index of erythrocytes indicate an unfavorable hemorheological situation in patients with major depressive disorder compared with healthy controls. The results of this study confirm the findings of studies finding a potential threat to cardiovascular health from major depressive disorder. Increased plasma viscosity and decreased erythrocyte elongation index in depressed patients may be risk factors for cardiovascular events and provide data on the causality of the association between depression and cardiovascular disease.
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