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Updated: Jul 4, 2025
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
Hepatocellular carcinoma combined with sarcomatoid hepatocellular carcinoma: A case report
Jingyi Li1, Xizhuang Gao1, Kun Zhao1
1Clinical Medical College of Jining Medical University, Jining Medical University, Jining, Shandong, P.R. China.
Rationale:
Sarcomatoid hepatocellular carcinoma (SHC) is an uncommon variant of hepatocellular carcinoma (HCC), characterized by HCC features combined with sarcomatoid histology and manifestations. The simultaneous occurrence of HCC and hepatosarcomatoid carcinoma is infrequent. This report presents a distinctive instance of HCC coexisting with hepatic sarcomatoid carcinoma in a 56-year-old male. The case exhibits an unusual clinical presentation, diagnosis, treatment, and prognosis. Through the presentation of this case, we aspire to contribute novel concepts to shape forthcoming strategies encompassing SHC diagnosis and treatment.
Patient Concerns:
The 56-year-old male patient was admitted to the hospital, due to discovering a hepatic mass lasting for over 2 months.
Diagnoses:
Ultimately, combined hepatocellular and SHC diagnosis was conclusively confirmed through histopathological and imaging examinations.
Intervention:
In this case, our approach encompassed hepatectomy coupled with ultrasound-guided radiofrequency ablation for HCC. Intraoperative ultrasound localization was employed for accurate tumor identification, followed by postoperative hepatic artery embolization to facilitate meticulous tumor resection.
Outcomes:
He underwent hepatic arteriography chemoembolization treatment and is currently stable, experiencing regular chemotherapy follow-up visits.
Lessons:
The presence of distinct tumor types concurrently can influence treatment choices and prognosis. Given the intricate nature of this condition, crafting an optimal treatment strategy necessitates the incorporation of variables such as the patient age, tumor characteristics, liver function, and other pertinent factors.
