Intracellular Synthesis of Indoles Enabled by Visible-Light Photocatalysis
Cinzia D'Avino1, Sara Gutiérrez1, Max J Feldhaus1
1Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), and Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15705 Santiago de Compostela, Spain.
Abstract:
Performing abiotic synthetic transformations in live cell environments represents a new, promising approach to interrogate and manipulate biology and to uncover new types of biomedical tools. We now found that photocatalytic bond-forming reactions can be added to the toolbox of bioorthogonal synthetic chemistry. Specifically, we demonstrate that exogenous styryl aryl azides can be converted into indoles inside living mammalian cells under photocatalytic conditions.
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