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Clinical manifestations and analytical reports for MDPHP acute intoxication cases
Davide Arillotta1, Arianna Totti2, Alexandra Dimitrova3
1Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology, University of Florence, Florence, Italy.
Journal of Pharmaceutical and Biomedical Analysis
|January 26, 2024
Summary
This study details 17 cases of MDPHP (a synthetic cathinone) intake, revealing severe psychiatric, neurological, and cardiotoxic symptoms. Advanced liquid chromatography-tandem mass spectrometry is crucial for detecting this potent substance.
Area of Science:
- Forensic Toxicology
- Pharmacology
- Clinical Chemistry
Background:
- MDPHP is a potent synthetic cathinone (SC) derivative of α-pyrrolidinophenone.
- SCs are central nervous system stimulants with potential for severe adverse effects.
- Limited case reports exist for MDPHP intoxication, necessitating further clinical and analytical investigation.
Purpose of the Study:
- To describe clinical manifestations and analytical findings in 17 cases of MDPHP intake.
- To highlight the diagnostic challenges and necessary advanced analytical techniques for SC detection.
- To inform healthcare providers and addiction specialists about MDPHP's associated risks.
Main Methods:
- Retrospective analysis of 17 cases with documented MDPHP intake.
- Quantification of MDPHP in blood and urine using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
- Clinical data collection including symptoms, comorbidities, and treatment outcomes.
Main Results:
- MDPHP detected in blood (1.26-73.30 ng/mL) and urine (19.31-8769.64 ng/mL).
- Observed severe psychiatric, neurological, respiratory symptoms, rhabdomyolysis, and cardiotoxicity.
- Concomitant use of other substances, especially psychostimulants, was common, complicating clinical assessment.
Conclusions:
- MDPHP intake is associated with severe and potentially life-threatening health consequences.
- Advanced analytical methods like LC-MS/MS are essential for accurate identification of MDPHP and other novel psychoactive substances (NPS).
- A multidisciplinary approach and increased awareness are crucial for managing MDPHP intoxication, particularly in vulnerable populations.
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