Related Experiment Video

Updated: Jul 4, 2025

Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures
08:02

Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures

Published on: July 27, 2022

2.5K

Role of Platelet-Derived Growth Factor-mediated signaling in carcinogenesis and metastasis

Ammad Ahmad Farooqi1, Rukset Attar2

  • 1Department of Molecular Oncology, Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan. Farooqiammadahmad@gmail.com.

Cellular and Molecular Biology (Noisy-Le-Grand, France)
|January 27, 2024
PubMed

Insights

Platelet-Derived Growth Factor (PDGF) signaling is crucial in cancer. Targeting this pathway with drugs shows promise for inhibiting cancer progression and metastasis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Platelet-Derived Growth Factor (PDGF) signaling is a key pathway in cancer development and progression.
  • Extensive preclinical and clinical data have elucidated the PDGF/PDGFR signaling landscape.
  • Therapeutic targeting of the PDGF/PDGFR axis is essential for improving patient outcomes.

Purpose of the Study:

  • To review the involvement of PDGF/PDGFR signaling in various cancers.
  • To discuss the potential of pharmacological targeting of this cascade to inhibit cancer progression.

Main Methods:

  • Review of existing high-impact research and clinical studies.
  • Analysis of preclinical and genotype-driven studies.
  • Focus on the crosstalk between PDGF/PDGFR signaling and other transduction cascades.

Main Results:

  • PDGF/PDGFR signaling plays a significant role in primary tumor invasion, dissemination, and metastasis.
  • Kinase inhibitor drug discovery programs are expanding to target various kinases, including those in the PDGF pathway.
  • Targeting PDGF/PDGFR signaling demonstrates proof-of-concept for therapeutic intervention.

Conclusions:

  • The PDGF/PDGFR signaling pathway is a critical target for cancer therapy.
  • Pharmacological inhibition of PDGF/PDGFR signaling can effectively impede cancer progression.
  • Understanding the crosstalk with other signaling pathways is vital for comprehensive therapeutic strategies.

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