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Updated: Jul 4, 2025

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

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PP2A drives the stemness in colorectal cancer cells by decreasing the Hippo signaling pathway

Meng Wang1, Ting Chen2, Jie Zhang1

  • 1Center of Gastrointestinal and Minimally Invasive Surgery, Department of General Surgery, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, 610031, China. qiuping00754@163.com.

Cellular and Molecular Biology (Noisy-Le-Grand, France)
|January 27, 2024
PubMed

Insights

This study reveals how Protein Phosphatase 2A (PP2A) influences colorectal cancer (CRC) stemness via the Hippo signaling pathway. Findings highlight PP2A and circRNA hsa-circ-001680 as potential therapeutic targets for CRC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Colorectal cancer (CRC) is a leading cause of cancer-related mortality.
  • The Hippo signaling pathway is critical for regulating stemness in various cancers, including CRC.
  • Protein Phosphatase 2A (PP2A) has been implicated in tumorigenesis and Hippo pathway regulation.

Purpose of the Study:

  • To elucidate the role of PP2A in colorectal cancer stemness.
  • To investigate the interaction between PP2A, the Hippo signaling pathway, and CRC stemness.
  • To explore the regulatory mechanisms involving PP2A, circRNA hsa-circ-001680, and CRC progression.

Main Methods:

  • In vitro and in vivo experiments were conducted to assess PP2A's function in CRC.
  • Molecular mechanisms underlying PP2A-mediated Hippo pathway regulation of CRC stemness were investigated.
  • The association between PP2A, the Hippo pathway, and circRNA hsa-circ-001680 was examined, including PP2A expression and stability regulation by the circRNA.

Main Results:

  • PP2A plays a significant role in regulating colorectal cancer stemness through the Hippo signaling pathway.
  • The study identified PP2A as a key mediator in CRC progression.
  • CircRNA hsa-circ-001680 was found to regulate PP2A expression and stability, influencing CRC stemness.

Conclusions:

  • PP2A is a crucial regulator of CRC stemness via the Hippo pathway.
  • The interplay between PP2A, the Hippo pathway, and hsa-circ-001680 offers novel insights into CRC pathogenesis.
  • Targeting the PP2A-mediated pathway presents a potential therapeutic strategy for colorectal cancer treatment.

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