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A Comprehensive Review on Polyphenols based Nanovesicular System for Topical Delivery
Anshu Singh1, Zeeshan Fatima1, Dipti Srivastava2
1Department of Pharmacy, Amity Institute of Pharmacy, Lucknow, Amity University Uttar Pradesh Lucknow, Noida, 201313, India.
Current Drug Delivery
|January 27, 2024
Summary
Polyphenols, natural compounds from plants, show promise for skin disorders when delivered via nanovesicles. These systems enhance polyphenol properties and efficacy for topical applications, potentially replacing other therapies.
Area of Science:
- Pharmacology
- Dermatology
- Nanotechnology
Background:
- Polyphenols are plant metabolites with antioxidant, anti-inflammatory, and antimicrobial properties.
- Their natural abundance in colorful fruits and vegetables makes them ideal for targeting skin conditions.
- These compounds possess significant potential for treating various dermatological disorders.
Purpose of the Study:
- To explore polyphenol-loaded nanovesicles for treating skin disorders.
- To review the efficacy of different vesicular systems encapsulating polyphenols for dermatological applications.
- To identify opportunities for future research in polyphenol-based drug delivery systems for skin.
Main Methods:
- Literature search conducted across Web of Science, PubMed, Scopus, and Google Scholar.
- Results filtered based on titles, abstracts, and full-text availability.
- Systematic review of existing research on polyphenol nanovesicular formulations for skin.
Main Results:
- Various nanovesicles (liposomes, niosomes, ethosomes, transferosomes) incorporating polyphenols have been developed.
- These nanovesicular systems demonstrate improved physicochemical properties for skin delivery.
- Enhanced pharmacological action observed in polyphenol-loaded nanovesicles.
Conclusions:
- Polyphenol-based nanovesicular formulations are effective for topical drug delivery.
- These advanced systems may reduce reliance on less effective conventional skin therapies.
- Nanovesicles offer a promising platform for developing novel treatments for skin disorders.
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