Recent advances in dietary androgen receptor inhibitors

Area of Science:

• Endocrinology and Molecular Biology
• Nutritional Science
• Oncology

Background:

• The androgen receptor (AR) is vital for male development and prostate health, but its dysregulation contributes to prostatic diseases, including prostate cancer.
• Epidemiological studies suggest dietary factors, such as green tea and soy, may lower prostate cancer risk.
• Current synthetic antiandrogens have limitations, driving the search for alternative therapies.

Purpose of the Study:

• To review the structure and function of the androgen receptor (AR).
• To elucidate the mechanisms of action for existing antiandrogens.
• To summarize research on natural AR inhibitors from dietary sources and their potential role in preventing prostatic diseases.

Main Methods:

• Literature review of experimental, epidemiological, and clinical studies.
• Analysis of the structural basis for AR antagonism.
• Focus on natural compounds from edible plants, folk medicines, and supplements.

Main Results:

• Natural compounds from edible plants and traditional medicines act as AR inhibitors.
• Dietary intake of natural antiandrogens is associated with a reduced risk of prostatic diseases.
• Natural products present advantages over synthetic antiandrogens.

Conclusions:

• Natural AR inhibitors offer a promising avenue for nutritional intervention against prostatic disorders.
• Further research into dietary-derived AR inhibitors could lead to novel strategies for managing prostate health.
• This review provides an updated overview of natural antiandrogens for preventing prostate diseases.