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mRNA vaccine boosters and impaired immune system response in immune compromised individuals: a narrative review

Alberto Boretti1

  • 1Melbourne Institute of Technology, The Argus, 288 La Trobe St, Melbourne, VIC 3000, Australia. a.a.boretti@gmail.com.

Clinical and Experimental Medicine
|January 27, 2024
PubMed

Insights

Recent studies suggest a link between mRNA COVID-19 vaccine boosters and potential immune system impairment. Multiple doses may increase IgG4 antibodies and affect T cell activation, impacting the vaccine

Area of Science:

  • Immunology
  • Vaccinology
  • Public Health

Background:

  • Growing evidence over 24 months suggests a correlation between mRNA COVID-19 vaccine boosters and increased prevalence of COVID-19 infection and other pathologies.
  • Recent research indicates a potential causal link between these boosters and adverse health outcomes.

Purpose of the Study:

  • To investigate the potential for mRNA vaccine boosters to impair immune system response, particularly in immunocompromised individuals.
  • To evaluate the impact of multiple mRNA vaccine doses on specific immune markers.

Main Methods:

  • Analysis of recent scientific literature and studies examining immune responses post-mRNA COVID-19 vaccination.
  • Focus on immunological markers including IgG4 antibody levels and T cell activation (CD4+ and CD8+).

Main Results:

  • Multiple mRNA vaccine doses may lead to significantly elevated levels of IgG4 antibodies.
  • Potential for impaired activation of CD4+ and CD8+ T cells observed.

Conclusions:

  • mRNA vaccine boosters might impair immune system function in certain populations.
  • The potential for immune system impairment necessitates careful consideration of the cost-benefit ratio of booster programs.
Keywords:
CD4 + T cellsCD8 + T cellsCOVID-19IgG 4 antibodiesVaccines

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