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Related Experiment Videos

Buspirone attenuates volitional alcohol intake in the chronically drinking monkey.

D M Collins, R D Myers

    Alcohol (Fayetteville, N.Y.)
    |January 1, 1987
    PubMed
    Summary

    Buspirone, an anxiolytic drug, significantly reduced alcohol consumption in macaque monkeys. The effect was dose-dependent, with higher doses showing greater attenuation of alcohol intake.

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    Area of Science:

    • Pharmacology
    • Neuroscience
    • Behavioral Science

    Background:

    • Excessive alcohol consumption is a significant public health concern.
    • Previous research has explored various pharmacological interventions for alcohol use disorders.
    • Intracerebroventricular injections of human cerebrospinal fluid previously altered alcohol consumption in these subjects.

    Purpose of the Study:

    • To investigate the anxiolytic compound buspirone's effect on alcohol consumption patterns.
    • To determine if parenteral administration of buspirone alters established alcohol drinking behavior in macaques.

    Main Methods:

    • Four macaques with high alcohol preference were used.
    • Buspirone was administered intramuscularly at doses of 1.25, 5.0, and 20.0 mg/kg.
    • Alcohol and water intake were measured before, during, and after buspirone administration.

    Main Results:

    • Saline and the lowest dose (1.25 mg/kg) of buspirone had no effect on alcohol intake.
    • Higher doses (5.0 and 20.0 mg/kg) of buspirone significantly reduced alcohol consumption by 30-60%.
    • Alcohol intake returned to baseline levels after buspirone treatment cessation.

    Conclusions:

    • Buspirone exhibits dose-dependent anti-drinking effects in non-human primates.
    • This suggests potential therapeutic applications for buspirone in managing alcohol consumption.
    • Further research is warranted to explore the mechanisms underlying buspirone's effect on alcohol intake.

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