Endoscopic ultrasound-guided tissue acquisition for comprehensive genomic profiling.

Area of Science:

• Oncology
• Gastroenterology
• Genomics

Background:

• Next-generation sequencing advances enable comprehensive genomic profiling (CGP) in clinical practice.
• CGP is vital for personalized treatment strategies in pancreaticobiliary cancers.
• Sufficient high-quality tumor tissue samples are essential for effective CGP.

Purpose of the Study:

• To review the role of endoscopic ultrasound-guided tissue acquisition (EUS-TA) for CGP.
• To focus on the application of EUS-TA in pancreatic and biliary tract cancers.
• To highlight the importance of EUS-TA for endosonographers in the context of CGP.

Main Methods:

• Review of current literature and clinical practices.
• Focus on EUS-TA techniques for pancreatic cancer.
• Focus on EUS-TA techniques for biliary tract cancer.

Main Results:

• EUS-TA is a key method for obtaining tumor tissue for CGP.
• The review details the current status and significance of EUS-TA in pancreaticobiliary oncology.
• Endosonographers play a critical role in successful EUS-TA for CGP.

Conclusions:

• EUS-TA is indispensable for performing CGP in pancreaticobiliary cancers.
• Optimizing EUS-TA procedures is crucial for maximizing sample quality for genomic analysis.
• Integrating EUS-TA into routine practice supports individualized cancer treatment.