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Related Experiment Video

Updated: Jul 4, 2025

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
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Association of Peripartum Lactate Levels With Infection Outcomes.

Marijo N Aguilera, Sandra Hoffman, Whitney Wunderlich

    Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN
    |January 28, 2024
    PubMed
    Summary

    Lactate levels showed varied associations with maternal infection across pregnancy stages. Caution is advised when interpreting lactate for suspected sepsis, as it was not consistently linked to infection-related outcomes.

    Keywords:
    bacteremiaintraamniotic infectionlactatesepsis

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    Area of Science:

    • Obstetrics and Gynecology
    • Infectious Diseases
    • Clinical Chemistry

    Background:

    • Maternal infection poses risks during pregnancy and postpartum.
    • Lactate is a marker used in sepsis screening.
    • Understanding lactate's role across different obstetric periods is crucial.

    Purpose of the Study:

    • To investigate the association between lactate levels and maternal infection.
    • To determine if this association varies in the antepartum, intrapartum, and early postpartum periods.
    • To assess lactate's utility in identifying infection-related outcomes.

    Main Methods:

    • Retrospective observational cohort study of 783 women across 11 hospitals.
    • Analyzed lactate and blood culture tests for sepsis screening.
    • Used logistic regression and receiver operating characteristic curves to model associations.

    Main Results:

    • Lactate associated with antepartum bacteremia (OR 1.60) and intraamniotic infection (OR 1.57).
    • Higher lactate levels linked to composite infection outcomes (OR 1.41) across all periods.
    • Lactate threshold of 2.0 mmol/L showed poor sensitivity; antepartum lactate levels were lower.

    Conclusions:

    • Lactate's association with infection markers is inconsistent across antepartum, intrapartum, and postpartum periods.
    • Clinical interpretation of lactate levels for suspected sepsis requires caution.
    • Further research may refine lactate's role in obstetric infection management.