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Related Concept Videos

Polyprotic Acids03:38

Polyprotic Acids

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Acids are classified by the number of protons per molecule that they can give up in a reaction. Acids such as HCl, HNO3, and HCN that contain one ionizable hydrogen atom in each molecule are called monoprotic acids. Their reactions with water are:
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Solvating Effects02:12

Solvating Effects

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An understanding of the solvating effect helps rationalize the relation between solvation and acidity of the compound. In addition, this also explains the relative stability of conjugate bases for compounds with different pKa values. This lesson details, in-depth, the principle of solvating effects. The strength of an acid and the stability of its corresponding conjugate base are determined using pKa values. This observed relationship is a consequence of solvation, which is the interaction...
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Solubility is the measure of the maximum amount of solute that can be dissolved in a given quantity of solvent at a given temperature and pressure. Solubility is usually measured in molarity (M) or moles per liter (mol/L). A compound is termed soluble if it dissolves in water.
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Complexation Equilibria: Factors Influencing Stability of Complexes01:09

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In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
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Ionic Strength: Effects on Chemical Equilibria01:19

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The addition of an inert ionic compound increases the solubility of a sparingly soluble salt. For example, adding potassium nitrate to a saturated solution of calcium sulfate significantly enhances the solubility of calcium sulfate. Le Châtelier's principle cannot predict this shift in the equilibrium. Instead, this could be explained in terms of changes in the effective concentration of the ions in solution in the presence of added inert salt.
In this solution, the primary...
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Leveling Effect and Non-Aqueous Acid-Base Solutions02:11

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This lesson defines the leveling effect in acidic and basic solutions and its role in aqueous and non-aqueous solutions. It is essential to understand the competing nature of various species in a chemical system.
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A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
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Enhanced Physical Stability of L-Ascorbic Acid in an Ionic Liquid.

Takeshi Oshizaka1, Issei Takeuchi1, Katsuya Mukae2

  • 1Faculty of Pharmaceutical Sciences, Josai International University.

Chemical & Pharmaceutical Bulletin
|January 28, 2024
PubMed
Summary

Ionic liquid technology significantly stabilizes L-ascorbic acid (AA). This pyridoxine-based ionic liquid formulation prevented AA degradation over 28 days, unlike AA in water.

Keywords:
L-ascorbic acidionic liquidpyridoxinestability

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Area of Science:

  • Chemistry
  • Materials Science

Background:

  • L-ascorbic acid (AA) is a vital nutrient prone to degradation.
  • Enhancing AA stability is crucial for its applications.

Purpose of the Study:

  • To investigate the use of ionic liquid (IL) technology to improve L-ascorbic acid stability.
  • To evaluate the protective effect of a pyridoxine-based ionic liquid on AA.

Main Methods:

  • L-ascorbic acid was dissolved in water and a pyridoxine-based ionic liquid.
  • Degradation of AA was monitored over 28 days at 40°C in both formulations.

Main Results:

  • AA in water degraded significantly, with only 3.2% remaining after 7 days.
  • The ionic liquid formulation exhibited negligible degradation, preserving AA content over 28 days.

Conclusions:

  • Ionic liquid technology effectively enhances the stability of L-ascorbic acid.
  • Pyridoxine-based ionic liquids offer a promising approach for stabilizing AA.