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Treatment of Candida auris during extracorporeal life support: A case report
Paul Dobry1,2, Stephanie B Edwin1, Tsz Hin Ng1
1Department of Pharmacy, Ascension St. John Hospital, Detroit, MI, USA.
Abstract:
With rates of ECMO utilization on the rise, prevention of nosocomial infections is of paramount importance. Candida auris, an emerging highly pathogenic multidrug resistant fungus, is of particular concern as it is associated with persistent colonization of environmental surfaces, inability to be recognized by many diagnostic platforms, inconsistent laboratory susceptibility results, and high mortality rates. We describe a case of C. auris in a VV-ECMO patient successfully managed with a combination of anidulafungin, amphotericin B, and flucytosine.
Insights
Nosocomial infections are a growing concern with increased ECMO use. This case study details successful treatment of a Candida auris infection in a VV-ECMO patient using a combination antifungal therapy.
Area of Science:
- Infectious Diseases
- Mycology
- Critical Care Medicine
Background:
- Rising utilization of extracorporeal membrane oxygenation (ECMO) necessitates stringent infection prevention protocols.
- Candida auris, a multidrug-resistant fungus, poses significant challenges due to environmental persistence, diagnostic difficulties, and high mortality.
- Nosocomial fungal infections, particularly by C. auris, represent a critical threat in intensive care settings.
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