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Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
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Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection

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High prevalence of hepatitis B virus susceptibility among persons undergoing community-based hepatitis C virus

Catherine Campusano1,2, Rachel Kanner3, Claire McDonell4

  • 1Department of Medicine, School of Medicine, University of California, San Francisco, CA, USA. catherine.campusano@northwestern.edu.

Harm Reduction Journal
|January 28, 2024
PubMed

Insights

Many individuals with Hepatitis C virus (HCV) remain susceptible to Hepatitis B virus (HBV) infection, highlighting a critical gap in HBV vaccination. Integrating HBV vaccination with community-based HCV treatment is recommended.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Public Health

Background:

  • Coinfection with Hepatitis B virus (HBV) and Hepatitis C virus (HCV) is common due to shared transmission routes.
  • HBV vaccination is recommended for all HCV-infected individuals susceptible to HBV.
  • Identifying gaps in HBV vaccination is crucial for this high-risk population.

Purpose of the Study:

  • To determine HBV susceptibility patterns in individuals undergoing community-based HCV treatment.
  • To identify potential gaps in HBV vaccination coverage within this population.

Main Methods:

  • A cross-sectional study was conducted in two urban US community-based HCV treatment programs.
  • Participants were recruited via street outreach, targeting individuals experiencing homelessness and drug use.
  • Exclusion criteria included reactive HBsAg; cohort characteristics were obtained via surveys; descriptive analysis was performed.

Main Results:

  • Among 150 participants without chronic HBV, 31% were non-immune to HBV.
  • In current injection drug users (IDU), susceptibility was higher in younger age groups (31% aged 24-40, 47% aged 41-57).
  • Older participants (aged 58-74) showed higher HBV immunity (84%) due to prior exposure.

Conclusions:

  • A significant prevalence of HBV susceptibility exists among individuals receiving community-based HCV treatment.
  • Younger individuals with HCV, especially those reporting current IDU, show a notable gap in HBV vaccination.
  • Co-localizing HBV vaccination with HCV screening and treatment programs is suggested to address this gap.
Abstract

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