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Bridging Smart Nanosystems with Clinically Relevant Models and Advanced Imaging for Precision Drug Delivery.

Qiaoxia Zhou1,2,3, Qiongliang Liu1,4, Yan Wang5

  • 1Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), 85764, Munich, Germany.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
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Summary

Precision medicine requires understanding nano-drug-carrier (NDC) interactions for effective intracellular delivery. This review covers delivery methods, NDC properties, advanced models, and imaging techniques to improve NDC efficacy in clinical applications.

Keywords:
advanced imagingintracellular deliverynano‐bio interactionnano‐drug‐carriesphysiological models

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • Precision medicine necessitates a deep understanding of nano-drug-carrier (NDC) interactions for targeted intracellular delivery.
  • Current challenges include bridging the gap between in vitro, in vivo, and clinical applications of NDCs.

Purpose of the Study:

  • To provide a comprehensive review of strategies for enhancing intracellular NDC delivery.
  • To highlight the importance of multidisciplinary approaches in nano-biological interactions.

Main Methods:

  • Overview of in vitro membrane-disruption delivery methods (electroporation, sonoporation, photoporation, microfluidics, microinjection).
  • Analysis of NDC characteristics (size, shape, charge, hydrophobicity, elasticity) influencing cellular uptake.
  • Review of in vivo NDC systems and advanced pathophysiological models (in vitro/ex vivo).
  • Exploration of modern microscopy techniques for nanoparticle tracking.

Main Results:

  • In vitro methods offer high-throughput and efficient NDC delivery.
  • NDC properties significantly impact cellular uptake and targeting efficacy.
  • Advanced models and imaging techniques are crucial for translational research and clinical translation.

Conclusions:

  • Integrating nanosystem engineering, advanced models, and imaging tools is key to precise and efficient intracellular NDC delivery.
  • Future development of NDCs requires a holistic approach considering nano-biological interactions across different scales.
  • Bridging translational gaps through improved models and validation is essential for clinical success.