Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Red cell Th activation: biochemical studies.

J H Herman, W Whiteheart, R S Shirey

    British Journal of Haematology
    |February 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Blood transfusion safety in sub-Saharan Africa: A literature review of changes and challenges in the 21st century.

    Transfusion·2019
    Same author

    Blood donors with epilepsy continue to face unjustified discriminatory practices.

    Vox sanguinis·2018
    Same author

    A multicentre study investigating vital sign changes occurring in complicated and uncomplicated transfusions.

    Vox sanguinis·2017
    Same author

    Pathogen reduction and blood transfusion safety in Africa: strengths, limitations and challenges of implementation in low-resource settings.

    Vox sanguinis·2017
    Same author

    Antigen-matched red blood cell transfusions for patients with sickle cell disease at The Johns Hopkins Hospital.

    Immunohematology·2012
    Same author

    The impact of platelet transfusion characteristics on posttransfusion platelet increments and clinical bleeding in patients with hypoproliferative thrombocytopenia.

    Blood·2012
    Same journal

    Endocrinopathies and growth in a UK cohort of children with transfusion dependent thalassaemia.

    British journal of haematology·2026
    Same journal

    Comparative effectiveness of chimeric antigen receptor (CAR) T-cell therapy versus historical controls in patients with relapse/refractory aggressive B-cell lymphoma: An indirect treatment comparison in the real-world setting.

    British journal of haematology·2026
    Same journal

    Plasma metabolomics profile alterations in the onset and progression of paediatric immune thrombocytopenia.

    British journal of haematology·2026
    Same journal

    Carfilzomib, lenalidomide, and dexamethasone (KRd) versus bortezomib, lenalidomide, and dexamethasone (VRd) induction prior to autologous haematopoietic stem cell transplant/transplantation in newly diagnosed multiple myeloma.

    British journal of haematology·2026
    Same journal

    Immortal time bias limits the conclusion that post-transplant hypomethylating agent maintenance improves outcomes in myelodysplastic syndromes.

    British journal of haematology·2026
    Same journal

    Author response to Zhang and Chen.

    British journal of haematology·2026
    See all related articles

    The Th antigen on red blood cells in Fanconi's anemia differs from the T antigen. Peanut agglutinin studies reveal distinct molecular structures, challenging previous assumptions about their similarity.

    Area of Science:

    • Hematology
    • Immunology
    • Biochemistry

    Background:

    • Peanut agglutinin (PNA) binds to Th antigen on red blood cells.
    • Th antigen was presumed similar to T antigen, a desialylated form of glycophorin A/B.
    • T antigen also reacts with PNA.

    Purpose of the Study:

    • To investigate the molecular similarity between Th antigen and T antigen.
    • To characterize the Th antigen on red blood cells from Fanconi's anemia patients.

    Main Methods:

    • Used 125I-radiolabeled PNA and Western blotting on red blood cell membrane proteins.
    • Probed Th activated red blood cells for T antigen-related structures using [3H]sialic acid and sialyltransferase.

    Main Results:

    Related Experiment Videos

  • No T antigen-like structures were detected on Th activated red blood cells.
  • Western blotting did not reveal similarities between Th and T antigens.

    • Conclusions:

    • The Th antigen in Fanconi's anemia is qualitatively different from the T antigen.
    • This finding refutes the presumed similarity between these two red blood cell antigens.