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Updated: Jul 4, 2025
FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Preimplantation genetic testing: A remarkable history of pioneering, technical challenges, innovations, and ethical
Keith E Latham1,2,3
1Department of Animal Science, Michigan State University, East Lansing, Michigan, USA.
Abstract:
Preimplantation genetic testing (PGT) has emerged as a powerful companion to assisted reproduction technologies. The origins and history of PGT are reviewed here, along with descriptions of advances in molecular assays and sampling methods, their capabilities, and their applications in preventing genetic diseases and enhancing pregnancy outcomes. Additionally, the potential for increasing accuracy and genome coverage is considered, as well as some of the emerging ethical and legislative considerations related to the expanding capabilities of PGT.
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