Related Experiment Video

Updated: Jul 4, 2025

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
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Splicing DNA Damage Adaptations for the Management of Cancer Cells

Arun Kumar Singh1, Deepika Yadav1, Rishabha Malviya1

  • 1Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India.

Current Gene Therapy
|January 29, 2024
PubMed

Insights

Cancer cells evade apoptosis to metastasize. This review explores how DNA damage triggers apoptosis, crucial for chemotherapy and tumor removal.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Tumorigenesis and metastasis rely on cancer cells resisting apoptosis (programmed cell death).
  • Signal molecules are critical regulators of the highly controlled apoptotic process.
  • Apoptosis removes damaged cells, preventing tumor development.

Conclusions:

  • Understanding apoptosis mechanisms is vital for cancer therapy development.
  • Targeting apoptotic pathways holds promise for overcoming cancer drug resistance.
  • Further research into the interplay of signaling molecules can reveal new therapeutic strategies.
Keywords:
ApoptosisDNA damagecancerextrinsic pathwaygenetic therapy.p38 signaling

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