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Perinuclear lens retrodots: a role for ascorbate in cataractogenesis.
The British Journal of Ophthalmology
|February 1, 1987
Summary
Lens retrodots, associated with cataract, may indicate oxidative stress. These calcium oxalate deposits suggest reduced ascorbic acid levels in the aging eye, potentially identifying eyes vulnerable to damage.
Area of Science:
- Ophthalmology
- Biochemistry
- Cell Biology
Background:
- Lens retrodots are features in the adult lens, appearing after age 50.
- These structures are associated with the development of cataract.
- Their composition and origin have been areas of investigation.
Purpose of the Study:
- To investigate the composition and potential origin of lens retrodots.
- To explore the association between retrodots, ascorbic acid, and oxidative stress in the lens.
- To determine the prevalence of retrodots in cataractous eyes.
Main Methods:
- Analysis of retrodots in cataractous human lenses.
- In vivo and in vitro birefringence imaging.
- Chemical studies to determine elemental composition.
Main Results:
- Retrodots were observed in 39% of cataractous eyes studied.
- Birefringence confirmed their presence.
- Chemical analysis suggested calcium oxalate as a primary component.
- Ascorbic acid is proposed as the oxalate source.
Conclusions:
- Lens retrodots may be biomarkers of oxidative stress in the aging lens.
- Their presence suggests reduced ascorbic acid levels, compromising the eye's defense against oxidative damage.
- Retrodots could indicate lenses with diminished capacity to resist oxidative injury.