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Serum sRAGE levels in children with atopic dermatitis: a prospective study
Hatice Eke-Gungor1, Bilal Sagiroglu2, Zehra Nur Can-Coskun3
1Department of Paediatric Allergy and Immunology, University of Health Sciences, Kayseri City Training and Research Hospital, Kayseri, Turkey.
Postepy Dermatologii I Alergologii
|January 29, 2024
Summary
Serum soluble receptor for advanced glycation end products (sRAGE) levels are lower in children with atopic dermatitis (AD). This finding suggests sRAGE may play a role in AD pathogenesis.
Area of Science:
- Immunology
- Dermatology
- Biochemistry
Background:
- Atopic dermatitis (AD) is a chronic inflammatory skin condition.
- The receptor for advanced glycation end products (RAGE) is involved in inflammatory processes.
- Soluble RAGE (sRAGE) acts as a decoy receptor, potentially modulating RAGE-mediated inflammation.
Purpose of the Study:
- To investigate serum sRAGE levels in children diagnosed with atopic dermatitis.
- To explore the relationship between sRAGE levels and AD severity, atopy, and related biomarkers.
Main Methods:
- Diagnosis of AD was based on Hanifin and Rajka criteria.
- Disease severity was assessed using the Scoring Atopic Dermatitis (SCORAD) index.
- Serum sRAGE levels were quantified using ELISA, alongside skin prick testing (SPT), total IgE, and eosinophil counts.
Main Results:
- Children with AD exhibited significantly lower median serum sRAGE levels compared to healthy controls (8.43 vs. 14.09, p < 0.001).
- No significant correlation was found between sRAGE levels and AD severity, total IgE, or eosinophil counts.
- sRAGE levels did not differ significantly between AD subgroups with or without atopy.
Conclusions:
- Serum sRAGE levels are decreased in children with atopic dermatitis.
- sRAGE may be implicated in the pathophysiology of AD.
- Further research is warranted to elucidate the precise role of sRAGE in AD.
