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Highly Radiosensitive Diffuse Large B-cell Lymphoma of the Skull Treated With Low-Dose CyberKnife Radiotherapy: A
Shinichiro Mizumatsu1, Ryutaro Nomura2
1Cyberknife Center, Aoyama General Hospital, Toyokawa, JPN.
Cureus
|January 29, 2024
Summary
Low-dose CyberKnife radiotherapy (CKR) effectively controlled rare skull diffuse large B-cell lymphoma (DLBCL). This treatment achieved complete resolution of targeted and non-targeted lesions without adverse events.
Area of Science:
- Oncology
- Radiotherapy
- Hematology
Background:
- Diffuse large B-cell lymphoma (DLBCL) of the skull is an uncommon presentation.
- There are no prior reports on CyberKnife (CK) treatment for skull DLBCL.
Observation:
- A 75-year-old male initially diagnosed with skull metastases from renal pelvic cancer received CyberKnife radiotherapy (CKR).
- The patient's frontal bone lesion showed rapid shrinkage, leading to a reduced CKR dose.
- Post-treatment MRI revealed complete resolution of irradiated and non-irradiated skull lesions.
Findings:
- Histologic diagnosis confirmed DLBCL after initial misdiagnosis.
- Low-dose CKR resulted in effective local control of skull DLBCL.
- Complete resolution of targeted and non-targeted lesions was observed with minimal radiation dose to non-targeted areas.
Implications:
- This case highlights the importance of accurate diagnosis in managing rare oncologic presentations.
- Low-dose CKR demonstrates potential effectiveness and safety for treating skull DLBCL.
- Further research into CKR for skull DLBCL is warranted.
