Related Experiment Video
Updated: Jul 4, 2025
Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
Published on: September 26, 2018
Impact of medical checkup parameters on major adverse cardiovascular events in the general Japanese population
Tomonori Sugiura1, Hiroyuki Takase2, Yasuaki Dohi3
1Department of Cardiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
Insights
Medical checkups can identify cardiovascular risk. B-type natriuretic peptide levels measured during checkups strongly predict major adverse cardiovascular events (MACE), aiding early risk identification.
Area of Science:
- Cardiology
- Preventive Medicine
- Biomarker Research
Background:
- Medical checkups are crucial for identifying individuals at high cardiovascular risk.
- The specific impact of individual medical examination parameters on major adverse cardiovascular events (MACE) requires further investigation.
- Understanding these predictors is vital for refining cardiovascular risk assessment strategies.
Purpose of the Study:
- To identify predictors of MACE among parameters routinely examined during medical checkups in the general Japanese population.
- To assess the independent predictive value of various clinical parameters for future MACE.
- To evaluate the potential of incorporating specific biomarkers into routine checkups for enhanced cardiovascular risk stratification.
Main Methods:
- A cohort of 13,522 individuals undergoing medical checkups between 2008 and 2015 was followed for a median of 1,827 days.
- Major adverse cardiovascular events (MACE), including cardiovascular death, myocardial infarction, angina, heart failure, and stroke, were recorded as endpoints.
- Multivariate Cox hazard analysis was employed to determine independent predictors of MACE after adjusting for confounders.
Main Results:
- During follow-up, 196 participants experienced MACE.
- Univariate analysis indicated increased MACE risk associated with hypertension, diabetes mellitus, dyslipidemia, and metabolic syndrome.
- Multivariate analysis revealed male sex, age, systolic blood pressure, and baseline B-type natriuretic peptide (BNP) level as independent predictors of MACE, with BNP showing the most prominent impact.
Conclusions:
- Baseline B-type natriuretic peptide (BNP) level is a strong and independent predictor of future MACE in the general population.
- The inclusion of BNP measurement in routine medical checkups could significantly enhance the ability to identify individuals at increased cardiovascular risk.
- Integrating BNP testing may facilitate earlier intervention and improve cardiovascular disease prevention strategies.
Abstract:
Medical checkups play a role in the identification of individuals at increased cardiovascular risk. However, the impact of each medical examination parameter on the incidence of major adverse cardiovascular events (MACE) has not been intensively studied. Here we assessed the predictors of MACE among parameters examined during medical checkups in the general Japanese population. A total of 13,522 individuals (mean age, 52.8 ± 12.3 years) who participated in our medical checkup program from 2008 to 2015 were followed up for a median of 1,827 days with the endpoint of MACE. MACE included cardiovascular death, non-fatal myocardial infarction, angina, decompensated heart failure, stroke, and other cardiovascular events requiring hospitalization. Possible associations between MACE and baseline clinical test parameters were investigated. During follow-up, MACE occurred in 196 participants. Participants with hypertension, diabetes mellitus, dyslipidemia, or metabolic syndrome were at increased risk of MACE on the univariate analysis. Multivariate Cox hazard analysis demonstrated that male sex, age, systolic blood pressure, and baseline B-type natriuretic peptide level were independently correlated with future MACE after the adjustment for confounders; the impact of B-type natriuretic peptide was most prominent among the investigated variables. These results suggest that B-type natriuretic peptide level obtained during a medical checkup examination is an independent and strong predictor of MACE. The inclusion of BNP as part of medical checkup parameters may improve the ability to identify individuals at increased cardiovascular risk and prevent cardiovascular disease among them.
More Related Videos
Related Concept Videos
01:23Assessment of the Cardiovascular System I: Subjective Data
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
01:25Errors occurring during blood pressure monitoring
Several factors...
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:28Factors affecting Blood pressure
Physiological Factors:
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:20Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...