Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parentral Nutrition: Centeral and Peripheral Parental Nutrition01:27

Parentral Nutrition: Centeral and Peripheral Parental Nutrition

162
Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
162

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Poly(glutamic acid-<i>block</i>-tyrosine) peptides designed for gastrointestinal drug adsorption.

Journal of materials chemistry. B·2026
Same author

Modeling soil organic carbon stocks and changes in agricultural cropping systems using a decision support tool and process-based model.

Journal of environmental management·2026
Same author

A framework for building a synthetic cell from the SynCell Asia Initiative.

Nature biotechnology·2026
Same author

Cell death modalities modulate inflammatory and regenerative programs in zebrafish sensory organs.

Nature communications·2026
Same author

Cardiometabolic adaptations in the cave nectar bat Eonycteris spelaea.

Communications biology·2026
Same author

Mortality among workers at the Rocky Flats Plant, 1951-2017.

Journal of radiological protection : official journal of the Society for Radiological Protection·2026
Same journal

Stable, micron-scale lipocondensates achieving prolonged circulation without PEGlyated lipids.

Biomaterials science·2026
Same journal

Fiber and continuum scale contributions to the intrinsic and apparent fracture of soft collagenous tissue <i>via</i> cutting.

Biomaterials science·2026
Same journal

Surface morphology-regulated tissue adhesion in solid and mesoporous silica-reinforced gelatin nanocomposite hydrogels.

Biomaterials science·2026
Same journal

Nanostructured hyaluronic acid-chia mucilage film as bioactive wound dressings for accelerated skin regeneration.

Biomaterials science·2026
Same journal

Tunable bio-inspired hybrid hydrogels reprogram stem cell-derived extracellular vesicles for superior wound regeneration.

Biomaterials science·2026
Same journal

Bioorthogonally reinforced injectable granular hydrogels synergizing ECM mimicry with microporosity for skin tissue engineering.

Biomaterials science·2026
See all related articles

Related Experiment Video

Updated: Jul 4, 2025

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
09:57

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

Published on: July 13, 2019

13.0K

Color changing bioadhesive barrier for peripherally inserted central catheters.

Ivan Djordjevic1, Elizabeth Ellis1, Juhi Singh2,3

  • 1School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Ave, Block N4.1, Singapore 639798. wjsteele@ntu.edu.sg.

Biomaterials Science
|January 29, 2024
PubMed
Summary
This summary is machine-generated.

A new biosensor adhesive, CathoGlu, detects bacterial infections at catheter sites via color change and forms a protective barrier. This innovation aims to prevent serious complications like bloodstream infections (bacteraemia).

More Related Videos

Candida albicans Biofilm Development on Medically-relevant Foreign Bodies in a Mouse Subcutaneous Model Followed by Bioluminescence Imaging
08:31

Candida albicans Biofilm Development on Medically-relevant Foreign Bodies in a Mouse Subcutaneous Model Followed by Bioluminescence Imaging

Published on: January 27, 2015

13.0K
The Use of the Ex Vivo Chandler Loop Apparatus to Assess the Biocompatibility of Modified Polymeric Blood Conduits
10:15

The Use of the Ex Vivo Chandler Loop Apparatus to Assess the Biocompatibility of Modified Polymeric Blood Conduits

Published on: August 20, 2014

11.6K

Related Experiment Videos

Last Updated: Jul 4, 2025

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
09:57

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

Published on: July 13, 2019

13.0K
Candida albicans Biofilm Development on Medically-relevant Foreign Bodies in a Mouse Subcutaneous Model Followed by Bioluminescence Imaging
08:31

Candida albicans Biofilm Development on Medically-relevant Foreign Bodies in a Mouse Subcutaneous Model Followed by Bioluminescence Imaging

Published on: January 27, 2015

13.0K
The Use of the Ex Vivo Chandler Loop Apparatus to Assess the Biocompatibility of Modified Polymeric Blood Conduits
10:15

The Use of the Ex Vivo Chandler Loop Apparatus to Assess the Biocompatibility of Modified Polymeric Blood Conduits

Published on: August 20, 2014

11.6K

Area of Science:

  • Biomaterials Science
  • Infectious Disease Diagnostics
  • Medical Device Innovation

Background:

  • Bacteraemia originating from catheter insertion sites is a critical complication with high mortality.
  • Effective physical barriers at the skin-catheter interface are needed to prevent bacterial migration.

Purpose of the Study:

  • To design and evaluate CathoGlu, a novel colorimetric biosensor adhesive.
  • To assess its dual function as a bacterial infection detector and a physical barrier.
  • To ensure its safety and efficacy compared to existing medical adhesives.

Main Methods:

  • Development of a hydrophobic bioadhesive incorporating bromothymol blue for pH-based colorimetric detection.
  • UV-A light-induced liquid-to-biorubber transition for barrier formation.
  • OECD-recommended in vitro and in chemico assays for genotoxicity and skin sensitization.
  • In vivo evaluation in a porcine model comparing CathoGlu to Dermabond™ and Micropore™.

Main Results:

  • CathoGlu successfully distinguishes healthy skin (pH ~5) from infected sites (pH ~8) via visual color change.
  • The formulation solidifies into an elastic barrier upon UVA exposure.
  • Assays confirmed no genotoxic or skin sensitization effects.
  • CathoGlu demonstrated non-inferiority to Dermabond™ and Micropore™ in a porcine model.

Conclusions:

  • CathoGlu offers a novel approach for early detection and prevention of bacterial infections at catheter sites.
  • Its dual functionality as a diagnostic tool and protective barrier holds promise for preventing sepsis.
  • The safety and efficacy profile supports its potential use in clinical settings.